Skip to main content

BIO-CAT Patents and Publications

Ownable Differentiation

BIO-CAT strives to make a meaningful difference through new technology and research. Over the past 30 years BIO-CAT has 20+ patents issued or pending. BIO-CAT’s IP is inclusive of human therapeutics, ingredient processing and probiotic use.

Through our years of research, BIO-CAT has been published in multiple peer reviewed journals and continues publishing in prolific top journals today.

Publications

  • Garvey, S. M., Madden, E. N., Qu, Y., Best, C. H., & Tinker, K. M. (2025). The Effects of a Microbial Enzyme Mixture on Macronutrient Hydrolysis in a Static Simulation of Oro-Gastric Digestion That Models Human Digestive Senescence. Foods, 14(6), 937. https://doi.org/10.3390/foods14060937
  • Qu, Y., Tinker, K. M., Madden, E. N., Best, C. H., Farmar, J. G., & Garvey, S. M. (2025). Comparative evaluation of amylases in the oral phase of the INFOGEST static simulation of oro-gastric digestion. Food research international (Ottawa, Ont.), 203, 115887. https://doi.org/10.1016/j.foodres.2025.115887
  • Paulussen, K. J. M., Askow, A. T., Deutz, M. T., et al. (2024). Acute Microbial Protease Supplementation Increases Net Postprandial Plasma Amino Acid Concentrations after Pea Protein Ingestion in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. The Journal of Nutrition (published online, in press). https://doi.org/10.1016/j.tjnut.2024.03.009
  • Brutscher, L. M., Gebrechristos, S., Garvey, S. M., & Spears, J. L. (2024). Genetic and Phenotypic Characterization of Bacillus velezensis strain BV379 for Human Probiotic Applications. Microorganisms, 12, 436. https://doi.org/10.3390/microorganisms12030436
  • Garvey, S. M., Emami, N. K., Guice, J. L., et al. (2023). The Probiotic Bacillus subtilis MB40 Improves Immunity in a Porcine Model of Listeriosis. Microorganisms, 11, 2110. https://doi.org/10.3390/microorganisms11082110
  • Guice, J. L., Hollins, M. D., Farmar, J. G., et al. (2023). Microbial Inulinase Promotes Fructan Hydrolysis under Simulated Gastric Conditions. Frontiers in Nutrition, 10, 1129329. https://doi.org/10.3389/fnut.2023.1129329
  • Garvey, S. M., Mah, E., Blonquist, T. M., et al. (2022). The Probiotic Bacillus subtilis BS50 Decreases Gastrointestinal Symptoms in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Gut Microbes, 14, 2122668. https://doi.org/10.1080/19490976.2022.2122668
  • Brutscher, L. M., Borgmeier, C., Garvey, S. M., & Spears, J. L. (2022). Preclinical Safety Assessment of Bacillus subtilis BS50 for Probiotic and Food Applications. Microorganisms, 10, 1038. https://doi.org/10.3390/microorganisms10051038
  • Garvey, S. M., Guice, J. L., Hollins, M. D., et al. (2022). Fungal Digestive Enzymes Promote Macronutrient Hydrolysis in the INFOGEST Static In Vitro Simulation of Digestion. Food Chemistry, 386, 132777. https://doi.org/10.1016/j.foodchem.2022.132777
  • Spears, J. L., Kramer, R., Nikiforov, A. I., et al. (2021). Safety Assessment of Bacillus subtilis MB40 for Use in Foods and Dietary Supplements. Nutrients, 13, 733. https://doi.org/10.3390/nu13030733
  • Penet, C., Kramer, R., Little, R., et al. (2019). A Randomized, Double-Blind, Placebo-Controlled, Parallel Study Evaluating the Efficacy of Bacillus subtilis MB40 to Reduce Abdominal Discomfort, Gas, and Bloating. Alternative Therapies in Health and Medicine, 25, 146–157. http://alternative-therapies.com/oa/6199.html
  • Do, D. H., Kong, F., Penet, C., et al. (2016). Using a Dynamic Stomach Model to Study Efficacy of Supplemental Enzymes during Simulated Digestion. LWT – Food Science and Technology, 65, 580–588. https://doi.org/10.1016/j.lwt.2015.08.054

Patents

BIO-CAT holds over 20 patents in the fields of probiotic applications, enzyme therapeutics, and enzyme processing.

Learn About Our Services

Custom Formulation

The right enzyme or microbial for your precise application

Custom Blending

Large blending capacity, production and packaging

Custom Product Development

Your partner in innovating new products

Custom R&D Projects

From basic research through development and tech support

Quality Assurance & Control Support

Every product rigidly tested in our in-house lab

Regulatory Support

Regulation review, safety, import/export and more

Explore our Resources

Learn about enzymes, probiotics and microbials in our resource library.

Binders in a row

Let’s Develop Something Together

We’re as passionate as you are about scientific innovation that matters

Learn More