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BIO-CAT Patents and Publications

Ownable Differentiation

BIO-CAT strives to make a meaningful difference through new technology and research. Over the past 30 years BIO-CAT has composed 14 patents and has three patents pending. BIO-CAT’s IP is inclusive of human therapeutics, ingredient processing and probiotic use.

Through our years of research, BIO-CAT has been published in multiple peer reviewed journals and continues publishing in prolific top journals today.


Brutscher LM, Borgmeier C, Garvey SM, Spears JL. Preclinical Safety Assessment of Bacillus subtilis BS50 for Probiotic and Food Applications. Microorganisms. 2022;10(5):1038.

Garvey SM, Guice JL, Hollins MD, et al. Fungal Digestive Enzymes Promote Macronutrient Hydrolysis in the INFOGEST Static In Vitro Simulation of Digestion. Food Chemistry. 2022;386:132777.

Spears JL, Kramer R, Nikiforov AI, et al. Safety Assessment of Bacillus subtilis MB40 for Use in Foods and Dietary Supplements. Nutrients. 2021;13(3).

Penet C, Kramer R, Little R, et al. A Randomized, Double-Blind, Placebo-Controlled, Parallel Study Evaluating the Efficacy of Bacillus subtilis MB40 to Reduce Abdominal Discomfort, Gas, and Bloating. Alternative Therapies in Health and Medicine. 2019;25(12).


BIO-CAT holds multiple patents in the fields of probiotic applications, enzyme therapeutics, and enzyme processing.

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