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BIO-CAT Patents and Publications

Ownable Differentiation

BIO-CAT strives to make a meaningful difference through new technology and research. Over the past 30 years BIO-CAT has composed 14 patents and has three patents pending. BIO-CAT’s IP is inclusive of human therapeutics, ingredient processing and probiotic use.

Through our years of research, BIO-CAT has been published in multiple peer reviewed journals and continues publishing in prolific top journals today.


  • Paulussen, K. J. M., Askow, A. T., Deutz, M. T., et al. (2024). Acute Microbial Protease Supplementation Increases Net Postprandial Plasma Amino Acid Concentrations after Pea Protein Ingestion in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. The Journal of Nutrition (published online, in press).
  • Brutscher, L. M., Gebrechristos, S., Garvey, S. M., & Spears, J. L. (2024). Genetic and Phenotypic Characterization of Bacillus velezensis strain BV379 for Human Probiotic Applications. Microorganisms, 12, 436.
  • Garvey, S. M., Emami, N. K., Guice, J. L., et al. (2023). The Probiotic Bacillus subtilis MB40 Improves Immunity in a Porcine Model of Listeriosis. Microorganisms11, 2110.
  • Guice, J. L., Hollins, M. D., Farmar, J. G., et al. (2023). Microbial Inulinase Promotes Fructan Hydrolysis under Simulated Gastric Conditions. Frontiers in Nutrition, 10, 1129329.
  • Garvey, S. M., Mah, E., Blonquist, T. M., et al. (2022). The Probiotic Bacillus subtilis BS50 Decreases Gastrointestinal Symptoms in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Gut Microbes14, 2122668.
  • Brutscher, L. M., Borgmeier, C., Garvey, S. M., & Spears, J. L. (2022). Preclinical Safety Assessment of Bacillus subtilis BS50 for Probiotic and Food Applications. Microorganisms10, 1038.
  • Garvey, S. M., Guice, J. L., Hollins, M. D., et al. (2022). Fungal Digestive Enzymes Promote Macronutrient Hydrolysis in the INFOGEST Static In Vitro Simulation of Digestion. Food Chemistry386, 132777.
  • Spears, J. L., Kramer, R., Nikiforov, A. I., et al. (2021). Safety Assessment of Bacillus subtilis MB40 for Use in Foods and Dietary Supplements. Nutrients13, 733.
  • Penet, C., Kramer, R., Little, R., et al. (2019). A Randomized, Double-Blind, Placebo-Controlled, Parallel Study Evaluating the Efficacy of Bacillus subtilis MB40 to Reduce Abdominal Discomfort, Gas, and Bloating. Alternative Therapies in Health and Medicine25, 146–157.
  • Do, D. H., Kong, F., Penet, C., et al. (2016). Using a Dynamic Stomach Model to Study Efficacy of Supplemental Enzymes during Simulated Digestion. LWT – Food Science and Technology, 65, 580–588.


BIO-CAT holds over 20 patents in the fields of probiotic applications, enzyme therapeutics, and enzyme processing.

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